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Gadolinium
is a rare earth metal used in magnetic resonance imaging
known as an MRI. One of the most serious side effects of
Gadolinium is that it has been known to cause
Nephrogenic Systemic Fibrosis, which is a disorder that
causes extensive tissue fibrosis. Tim D. Wilson
Investigations is currently researching Gadolinium in
order to bring public knowledge of the dangerous side
effects which can be developed from the use of this
metal in MRIs. Patients who are at risk the most are
those with pre-existing kidney disease.
The type of MRI in which Gadolinium is most commonly
used is called a Magnetic Resonance Angiography or an
MRA. In this particular type of MRI pictures are taken
of the blood vessels in the body. The use of Gadolinium
in this procedure is to enhance the images of these
pictures. In order for Gadolinium to be effective in
these procedures the dose has to be administered at
three times the approved dose. The problem with
administering Gadolinium in this high of a dose is that
the body can not extract all of it, causing the patient
to become more at risk of serious side effects. One of
the biggest concerns about the use of Gadolinium in this
procedure is that the Food and Drug Administration has
never approved Gadolinium for this type of use, though
it is becoming more and more popular in these types of
MRI's.
Serious side effects have been linked to the use of
Gadolinium. The most common side effect is the
development of Nephrogenic Systemic Fibrosis or NSF. NSF
is a serious condition and can lead to death if the
patient does not immediately receive dialysis. Another
disease that has also been linked to the use of
Gadolinium based MRI's is Nephrogenic Fibrosing
Dermopathy or NFD. This is the fibrosis condition which
is found in the skin. One statement by the FDA is that
there are approximately 215 patients with NSF worldwide.
Of the 215 patients approximately 75 of these people had
received MRI's with the Gadolinium agent. The FDA also
adds that they are not certain why patients with
moderate to end-stage kidney disease develop NSF after
receiving Gadolinium based MRI's. Some of the top
physicians have warned people who have advanced kidney
disease not to undergo MRI's where gadolinium is used.
Some of the most common brand names of Gadolinium based
dyes used in MRIs include Omniscan by GE healthcare,
Prohance by Bracco Diagnostics, OptiMARK by
Mallinckrodt/Tyco Healthcare, Magnevist by
Bayer/Schering AG/Berlex, and Multihance by Bracco
Diagnostics. If you have received MRIs using these dyes
you might be at risk.
Some of the early warning signs of NSF or NFD can be
burning, swelling, itching, tightening or hardening of
the skin. Other signs include stiffening joints, yellow
or white spots in the eyes, muscle weakness, and red or
dark patches located on the skin. If you suffer from any
of these symptoms following the administration of
Gadolinium you might be at risk of serious injury.
If you or a loved one has suffered from the dangerous
side effects associated with Gadolinium, please contact
our office so that we may assist you in winning your
case.
Other Pharmaceutical
Investigations / Research:
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